Eleveld Cet calculator

Enter age:
BIS 46: 3.4 μg/mL
BIS 60: 1.9 μg/mL
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References

The formulas being used have been extrapolated from the articles below:
  • BIS 60 = 4.0 - (age x 0.01) ie. 0.1 per decade of age
  • BIS 46 = 4.0 - (age x 0.02) ie. 0.2 per decade of age
1. Eleveld DJ, Colin P, Absalom AR, Struys M. Pharmacokinetic-pharmacodynamic model for propofol for broad application in anaesthesia and sedation. Br J Anaesth. 2018;120(5):942-59.
Figure 1. Relationships between effect-site concentration and predicted BIS, and the relationship between age and effect-site concentration for 50% and 10% drug effect for the final PK-PD model. BIS, bispectral index. (1)
Correlation 1
2. Vellinga R, Hannivoort LN, Introna M, Touw DJ, Absalom AR, Eleveld DJ, et al. Prospective clinical validation of the Eleveld propofol pharmacokinetic-pharmacodynamic model in general anaesthesia. Br J Anaesth. 2021;126(2):386-94.
Figure 2. The relationship between target concentration and age for the Eleveld PK-PD model showing the expected drug effect and suppression of BIS values from baseline. BIS, bispectral index;PK-PD, pharmacokinetic-pharmacodynamic. (2)
Correlation 1